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SIADH

SIADH Syndrome of inappropriate antidiuretic hormone secretion: characterised by hyponatraemia, with urine sodium >20 mmol/L and urine osmolality > plasma osmolality. Osmolality - plasma and urine; sodium - plasma and urine; levels of creatinine, urea and urate tend to be low in SIADH but high in patients in whom hyponatraemia is associated with hypovolaemia. Hypothyroidism, Addison’s disease and diuretic therapy must be excluded on clinical or pathological findings.
  Malignancy  
    Carcinoma esp  
      Lung  
      Pancreas  
    Lymphoma (non-Hodgkins)  
  Respiratory disorders eg  
    Pneumonia  
    Tuberculosis  
    Lung abscess  
  Neurological disorders eg  
    Head injury  
    Subdural haematoma  
    Cerebral infarction  
    Subarachnoid haemorrhage  
    Encephalitis  
    Post-craniotomy  
  Drug effects eg  
    Chlorpropamide  
    Vincristine  
    Vinblastine  
    Cyclophosphamide  
    Carbamazepine  
    Narcotics  
    Tricyclic antidepressants  




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