PYRUVATE - blood

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Specimen: Specimen collection requirements should be discussed with the laboratory; tourniquet use should be avoided.

Method: Spectrophotometry.

Reference Interval: 0.03-0.10 mmol/L.

Application: Classification of genetic lactic acidosis, differentiating primary pyruvic acidaemia from lactic acidaemia.

Interpretation: Elevated lactate/pyruvate ratio indicates primary lactic acidosis. Normal lactate/pyruvate ratio indicates primary pyruvic acidosis (eg pyruvate dehydrogenase deficiency).

Reference: Stansbie D et al. J Inherit Met Dis 1986; 9: 105-119.

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