PEMPHIGUS ANTIBODIES - serum

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Also known as desmoglein antibodies.

Specimen: 10 mL blood in plain tube.

Method: Indirect IF.

Reference Interval: Not detected.

Application: Diagnosis of bullous skin diseases; differentiates pemphigus from pemphigoid.

Interpretation: Intercellular cement substance antibodies (also known as desmoglein antibodies) are specific for pemphigus. Titres correlate with disease activity and effect of treatment. Pemphigus-like antibodies occur in burns, drug reactions and other disorders with extensive skin damage.

Reference: Stanley J. J Exp Med. 1995; 181: 1-4.

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