LUPUS BAND TEST - skin
Specimen: Biopsy of normal,
non-sun-exposed skin and of affected skin. Specimens should not be placed in fixative
and should be transported rapidly to the laboratory on moist gauze.
Method: Direct IF.
Application: Diagnosis of systemic lupus erythematosus (SLE).
Interpretation:. Immunoglobulin and C3 deposition at the dermo-epidermal junction
of both lesional and normal skin is seen in SLE, whereas deposition in lesional,
but not normal skin occurs in discoid lupus. Sensitivity for SLE is 60%. Relatively
specific for SLE however any form of skin damage may cause basement membrane deposition
of immunoglobulin.
Reference: Harris TJ and Mihm MC. Arthr Rheum. 1980; 23: 479-490.
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