GLUTAMIC ACID DECARBOXYLASE (GAD) ANTIBODIES - serum

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Specimen: 5 mL blood in plain tube.

Method: Immunoassay.

Reference Interval: Not detected.

Application: The test is under evaluation for the identification of diabetic patients with a high risk of developing insulin dependence. See also ISLET CELL ANTIBODIES .

Interpretation: GAD antibodies are present in >70% of diabetic patients treated with insulin but only 10% of those maintained on oral hypoglycaemic agents.

Reference: Hagopian WA et al. J Clin Invest 1993; 91: 368-374.

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