GLOMERULAR BASEMENT MEMBRANE ANTIBODIES - serum

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Specimen: 5 mL blood in plain tube.

Method: Immunoassay, indirect IF. Immunoassay is the preferred method.

Reference Interval: Not detected.

Application: Diagnosis of Goodpasture syndrome . Assessment of rapidly progressive glomerulonephritis.

Interpretation: Glomerular basement membrane antibodies are highly predictive of Goodpasture syndrome; the definitive diagnosis of Goodpasture syndrome requires renal biopsy with IF.

Reference: Jayne D et al. Kidney Int. 1990; 37: 965-970.

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