DNA ANTIBODIES - serum

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Specimen: 5 mL blood in plain tube.

Method: Immunoassay.

Reference Interval: Method dependent - consult pathologist. Commonly <5 IU/mL.

Application: For confirmation of diagnosis or monitoring of SLE. Sensitivity approximately 70%.

Interpretation: High levels are strongly suggestive of active SLE, particularly with renal involvement. Lesser elevations may be found occasionally in other autoimmune disorders.

Reference: Borg EJ et al. Arthritis Rheum 1990; 33: 634-643.

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