DIC

DIC

DIC	Disseminated intravascular coagulation or defibrination syndrome. FBC , blood film , platelet count ; thrombin time , fibrin degradation products , fibrinogen assay to establish diagnosis. Platelet count , APTT , PT , fibrinogen assay to monitor course and therapy.
Acute severe DIC eg
Obstetric syndromes	See Peripartum bleeding under Pregnancy .
Septicaemia esp Gram-negative bacteria eg
Escherichia coli Neisseria meningitidis
Massive trauma
Acute promyelocytic leukaemia	See Acute leukaemia .
Acute intravascular haemolysis esp
ABO-incompatible transfusion	See Immediate haemolytic reactions under Blood transfusion - transfusion reactions.
Prostate surgery
Asphyxia
Snake bite
Sub-acute/chronic DIC eg	See also Microangiopathic haemolysis .
Advanced/metastatic carcinoma esp Mucinous adenocarcinoma	Presence of DIC can often be predicted from the clinical context; confirmatory tests may not be required.
Severe/advanced liver disease
Retained dead fetus	Monitoring is important ( platelet count , FDP, fibrinogen assay ) until fetus delivered, as acute and severe DIC may develop.
Haemangiomas