Cushing's syndrome

Cushing's syndrome

Cushing’s syndrome	Dexamethasone suppression test (overnight) and/or cortisol (free) - urine are performed initially, as normal results exclude Cushing’s syndrome. In patients with abnormal results, a dexamethasone suppression test (long) , incl ACTH levels, provides the definitive diagnosis and differentiates pituitary from adrenal causes. Electrolytes. Diagnostic imaging, as appropriate.
Cushing’s disease	Pituitary-dependent adrenal hyperplasia.
Corticotroph adenoma
Adrenal adenoma/carcinoma
Ectopic ACTH syndrome
Iatrogenic (corticosteroid therapy)