ANTIDEOXYRIBONUCLEASE B (AntiDNase B) ANTIBODIES - serum

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Specimen: 5-10 mL blood in plain tube.

Method: Inhibition of streptococcal DNase B activity.

Reference Interval: Method dependent.

Application: Suspected recent infection with Streptococcus pyogenes. AntiDNase B antibodies are more sensitive than the ASOT for the diagnosis of post-streptococcal glomerulonephritis and serious streptococcal skin infections eg necrotising fasciitis.

Interpretation: High titre indicates recent infection with Streptococcus pyogenes. The titre peaks at 4-6 weeks, but high levels persist for longer than the ASOT. Often used in conjunction with the ASOT. See also ANTISTREPTOLYSIN O TITRE .

Reference: Ayoub EM and Harden E. In: Rose NR et al eds. Manual of Clinical Laboratory Immunology. 4th ed. ASM Press 1992.

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